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SKF-86002
CAS No. 72873-74-6
SKF-86002( SKF86002 )
Catalog No. M15788 CAS No. 72873-74-6
SKF-86002 is a potent inhibitor of p38 MAPK with IC50 of 0.5-1 uM, inhibits LPS-induced IL-1 and TNF-α production in human monocyte with IC50 of 1 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
|
| 5MG | 68 | In Stock |
|
| 10MG | 115 | In Stock |
|
| 25MG | 214 | In Stock |
|
| 50MG | 318 | In Stock |
|
| 100MG | 470 | In Stock |
|
| 500MG | 1008 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSKF-86002
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NoteResearch use only, not for human use.
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Brief DescriptionSKF-86002 is a potent inhibitor of p38 MAPK with IC50 of 0.5-1 uM, inhibits LPS-induced IL-1 and TNF-α production in human monocyte with IC50 of 1 uM.
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DescriptionSKF-86002 is a potent inhibitor of p38 MAPK with IC50 of 0.5-1 uM, inhibits LPS-induced IL-1 and TNF-α production in human monocyte with IC50 of 1 uM; inhibits prostaglandin H2 (PGH2) synthase activity (IC50=120 uM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50=70 uM); blocks superoxide anion production in response to FMLP and reduces adhesion and chemotaxis in response to PAF or FMLP in human neutrophils; also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50=10 and 100 uM respectively), shows anti-inflammatory in vivo.
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In VitroWestern Blot Analysis Cell Line:U937 cells Concentration:10 μM Incubation Time:72 hours Result:Significantly reduced CD23 levels on IL-4-treated U937 cells.
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In VivoAnimal Model:Lewis rats, with adjuvant-induced arthritis (AA) Dosage:10 mg/kg, 30 mg/kg, 90 mg/kg Administration:Oral administration, daily, for 22 days Result:Significantly decreased hindleg volumes after injection of adjuvant.
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SynonymsSKF86002
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38MAPK
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number72873-74-6
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Formula Weight297.35
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Molecular FormulaC16H12FN3S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESFC1=CC=C(C2=C(C3=CC=NC=C3)N4C(SCC4)=N2)C=C1
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Chemical NameImidazo[2,1-b]thiazole, 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Griswold DE, et al. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70.
2. Nick JA, et al. J Clin Invest. 1997 Mar 1;99(5):975-86.
3. Lee JC, et al. Nature. 1994 Dec 22-29;372(6508):739-46.
4. Perregaux DG, et al. Mol Pharmacol. 1995 Sep;48(3):433-42.
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