SUVN-502( SUVN502 | Masupirdine )

Catalog No. M15690 CAS No. 701205-60-9

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HNMR

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Product Name

SUVN-502
Note

Research use only, not for human use.
Brief Description

SUVN-502 (SUVN502, Masupirdine) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM.
Description

SUVN-502 (SUVN502, Masupirdine) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM; shows high selectivity over 5-HT2A receptor and other 100 target sites; produces synergistic effects in extracellular levels of acetylcholine in the ventral hippocampus combined with donepezil and memantine; shows potential for treatment of Alzheimer's disease.Alzheimer Disease Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

SUVN502 | Masupirdine
Pathway

GPCR/G Protein
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

Neurological Disease
Indication

Alzheimer Disease

CAS Number

701205-60-9
Formula Weight

478.405
Molecular Formula

C21H24BrN3O3S
Purity

>98% (HPLC)
Solubility

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SMILES

CN1CCN(CC1)CC2=CN(C3=C2C=C(C=C3)OC)S(=O)(=O)C4=CC=CC=C4Br
Chemical Name

1-((2-bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole

1. Nirogi R, et al. J Med Chem. 2017 Mar 9;60(5):1843-1859. 2. Nirogi R, et al. J Pharm Biomed Anal. 2017 Apr 14;145:423-430.

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