Uric Acid

Research use only, not for human use.

An oxidation product, via xanthine oxidase, of oxypurines such as xanthine and hypoxanthine.

An oxidation product, via xanthine oxidase, of oxypurines such as xanthine and hypoxanthine. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals urate oxidase further oxidizes it to allantoin.

Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation.Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity.

Animal Model:Eight-week-old male C57BL/6J mice Dosage:250 mg/kg body weight Administration:P.o.Result:When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.

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Metabolic Enzyme/Protease

Phospholipase

Glycogen phosphorylase

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69-93-2

168.11

C5H4N4O3

>98% (HPLC)

Water: 60 mg/L (at 20 °C)

O=C1NC2=C(N1)C(=O)NC(=O)N2

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(-20℃)

With Ice Pack

≥ 2 years