Tubercidin

Research use only, not for human use.

An antibiotic and adenosine analog isolated from the bacterium Streptomyces tubercidicus with potential antineoplastic activity.

An antibiotic and adenosine analog isolated from the bacterium Streptomyces tubercidicus with potential antineoplastic activity; incorporates into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis; also exhibits antifungal and antiviral activities.(In Vitro):Tubercidin (7-Deazaadenosine) (0-10 nM; 14 days) has a dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells, and the IC50s of tubercidin were 3.4 nM and 3.7 nM for CFU-GM and BFU-E, respectively.(In Vivo):Tubercidin (7-Deazaadenosine) (intraperitoneal injection; 5 mg/kg; 10 days) in cooperation with NBMPR-P protects the mice from the lethality of tubercidin and allowed the repetition of the regimen for a second time with 100% survival.

Cell Cytotoxicity Assay Cell Line:Human bone marrow progenitor cells Concentration:0-10 nM Incubation Time:14 days Result:Had a dose-dependent inhibitory effect for CFU-GM and BFU-E.

Animal Model:Female CD1 miceDosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg; 10 days Result:Protectedthe mice from the lethality of tubercidin.

Sparsomycin A | 7-Deazaadenosine | NSC-56408

GPCR/G Protein

Antibacterial

DNA/RNA Synthesis

Infection

——

69-33-0

266.2533

C11H14N4O4

>98% (HPLC)

DMSO: ≥ 30 mg/mL

NC1=NC=NC2=C1C=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-β-D-ribofuranosyl-

(-20℃)

With Ice Pack

≥ 2 years