Amorolfine HCL( —— )

Catalog No. M22881 CAS No. 106614-68-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Amorolfine HCL
Note

Research use only, not for human use.
Brief Description

Amorolfine HCL is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine, a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase.
Description

Amorolfine HCL is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine, a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase. These enzymes can deplete ergosterol and cause ignosterol to accumulate in the fungal cytoplasmic cell membranes.
In Vitro

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In Vivo

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Synonyms

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Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibiotic
Research Area

Immune system/Infection
Indication

Onychomycosis

CAS Number

106614-68-0
Formula Weight

354
Molecular Formula

C21H36ClNO?
Purity

>98% (HPLC)
Solubility

DMSO:12.5 mg/mL (35.31 mM; Need ultrasonic);H2O:3.33 mg/mL (9.41 mM; Need ultrasonic)
SMILES

CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C.Cl
Chemical Name

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