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Norverapamil hydrochloride
CAS No. 67812-42-4
Norverapamil hydrochloride( ±)-Norverapamil hydrochloride | D591 hydrochloride )
Catalog No. M15590 CAS No. 67812-42-4
A calcium channel blocker and the main active metabolite of verapamil.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 112 | In Stock |
|
| 5MG | 107 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 315 | In Stock |
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| 50MG | 461 | In Stock |
|
| 100MG | 621 | In Stock |
|
| 200MG | 870 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNorverapamil hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA calcium channel blocker and the main active metabolite of verapamil.
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DescriptionA calcium channel blocker and the main active metabolite of verapamil.
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In VitroNorverapamil hydrochloride ((±)-Norverapamil hydrochloride) is similarly effective as verapamil at inhibiting isoniazid and rifampicin tolerance and killing of intracellular M. tuberculosis in the absence of other drugs. norverapamil, also inhibits macrophage-induced tolerance and achieves similar serum levels to verapamil. Verapamil and its major metabolite norverapamil were identified to be both mechanism-based inhibitors and substrates of CYP3A and reported to have non-linear pharmacokinetics in clinic.
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In VivoNorverapamil hydrochloride (9 mg/kg; p.o.), a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng?h/ml, and 41.6 ng/mL, respectively. Animal Model:Male Sprague-Dawley rats Dosage:9 mg/kg (Pharmacokinetic Study)Administration:Oral administration Result:t1/2=9.4 hours;AUC=260 ng?h/mL;Cmax=41.6 ng/mL.
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Synonyms±)-Norverapamil hydrochloride | D591 hydrochloride
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number67812-42-4
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Formula Weight477.036
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Molecular FormulaC26H37ClN2O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 31 mg/mL
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SMILESN#CC(C(C)C)(C1=CC=C(OC)C(OC)=C1)CCCNCCC2=CC=C(OC)C(OC)=C2.[H]Cl
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Chemical NameBenzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee YS, et al. Xenobiotica. 2012 Aug;42(8):766-74.
2. Adams KN, et al. J Infect Dis. 2014 Aug 1;210(3):456-66.
3. Sawicki W. Eur J Pharm Biopharm. 2002 Jan;53(1):29-35.
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