Cart
sales@molnova.com
KU-55933
CAS No. 587871-26-9
KU-55933( KU 55933 | KU55933 )
Catalog No. M15169 CAS No. 587871-26-9
KU-55933 is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
|
| 5MG | 41 | In Stock |
|
| 10MG | 58 | In Stock |
|
| 25MG | 98 | In Stock |
|
| 50MG | 154 | In Stock |
|
| 100MG | 268 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameKU-55933
-
NoteResearch use only, not for human use.
-
Brief DescriptionKU-55933 is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM.
-
DescriptionKU-55933 is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM, >100-fold selectivity against other members of the PIKK family kinases; inhibits ATM-dependent p53 Ser15 phosphorylation in U2OS osteosarcoma cells with IC50 of 0.3 uM, sensitizes the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin; also suppresses the replication of both wild-type and drug-resistant HIV-1 by sensitizing cells to retrovirus-induced cell death.
-
In Vitro——
-
In Vivo——
-
SynonymsKU 55933 | KU55933
-
PathwayCell Cycle/DNA Damage
-
TargetATM/ATR
-
RecptorATM|ATR|DNA-PK|mTOR|PI3K
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number587871-26-9
-
Formula Weight395.4946
-
Molecular FormulaC21H17NO3S2
-
Purity>98% (HPLC)
-
SolubilityDMSO: 80 mg/mL (Need ultrasonic)
-
SMILESO=C1C=C(N2CCOCC2)OC(C3=C4SC5=C(C=CC=C5)SC4=CC=C3)=C1
-
Chemical Name4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hickson I, et al. Cancer Res. 2004 Dec 15;64(24):9152-9.
2. Lau A, et al. Nat Cell Biol. 2005 May;7(5):493-500.
3. Soriani A, et al. Blood. 2009 Apr 9;113(15):3503-11.
molnova catalog
related products
-
GJ103 sodium salt
A novel small molecular read-through (SMRT) compound that can induce read through of nonsense mutations in the ATM gene.
-
AZ-31
A potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM.
-
GSK 635416A
GSK 635416A is a novel ATM inhibitor with highly selective radiosensitizing activity, inhibits radiation induced phosphorylation of ATM.
