Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - GAT - AZD 3043

AZD 3043

CAS No. 579494-66-9

AZD 3043( THRX-918661 )

Catalog No. M15126 CAS No. 579494-66-9

AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 686 In Stock
10MG 938 In Stock
25MG 1444 In Stock
50MG 1841 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AZD 3043
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM.
  • Description
    AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM; potentiates and directly activates the α1β2γ2, α2β2γ2 and α2β3γ2 GABA(A) receptor subtypes, produces hypnosis and electroencephalograph depression in rats.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    THRX-918661
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GAT
  • Recptor
    GAT
  • Research Area
    Neurological Disease
  • Indication
    Depression

Chemical Information

  • CAS Number
    579494-66-9
  • Formula Weight
    351.443
  • Molecular Formula
    C19H29NO5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCOC(=O)Cc1ccc(c(c1)OCC)OCC(=O)N(CC)CC
  • Chemical Name
    [4-[(N,N-Diethylcarbamoyl)methoxy]-3-ethoxyphenyl]acetic acid propyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Egan TD, et al. Anesthesiology. 2012 Jun;116(6):1267-77. 2. Jonsson Fagerlund M, et al. Eur J Pharmacol. 2012 Nov 5;694(1-3):13-9. 3. Bj?rnsson MA, et al. Anesth Analg. 2015 Oct;121(4):904-13.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • PK-14105

    A potent photoaffinity ligand for the peripheral-type benzodiazepine binding site with Ki of 4 nM.

  • CI-966

    CI-966 (PD 126141) is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively.

  • (R)-Baclofen

    A derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist; also blocks α2δ subunit-containing voltage-dependent calcium channel (VDCC) with Ki of 156 uM.

Sign In Join Free