Dyclonine hydrochloride

Research use only, not for human use.

Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge.

Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge.(In Vitro):Dyclonine hydrochloride (50 μM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH.Dyclonine hydrochloride (0-2048 μg/mL; 24 or 48 h) shows significant bactericidal and fungicidal activity. (In Vivo):Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo.Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine.

Dyclonine hydrochloride (50 μM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH.Dyclonine hydrochloride (0-2048 μg/mL; 24 or 48 h) shows significant bactericidal and fungicidal activity. Cell Viability Assay Cell Line:HSC-4 cells Concentration:50 μM Incubation Time:24 hResult:Inhibited ALDH activity and induced 4-HNE accumulation in GSH-depleted cancer cells.Cell Viability Assay Cell Line:S. aureus, B. subtilis, E. coli, T. mentagrophyteConcentration:0-2048 μg/mL Incubation Time:24 h (for bacterial), 48 h (for fungi) Result:Showed good antibacterial and antifungal activity, with minimum microbicidal concentration of 0.006%, 0.025%, 0.012% and 0.025% for S. aureus, B. subtilis, E. coli, T. mentagrophyte, separately.

Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo.Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine. Animal Model:Athymic nude mice (HSC-2 cells implanted model).Dosage:5 mg/kg Administration: Intraperitoneal injection; single daily for 24 days (combine with sulfasalazine).Result:Attenuated the formation of tumors by HSC-2 cells implanted in nude mice when combined with sulfasalazine.Animal Model:C57BL6 mice (K19-Wnt1/C2mE-KP cells implanted model).Dosage:5 mg/kg Administration:Intraperitoneal injection; single daily for 21 days (combine with sulfasalazine).Result:Enhanced the antitumor effect of sulfasalazine on HNSCC tumors consisting of CD44vhigh stemlike tumor cells and involucrin+ differentiated tumor cells.

Dyclonine Hydrochloride | Dyclonine HCL | Dyclone | Dyclothane | Tanaclone | Sucrets | Tanac

Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Neurological Disease

——

536-43-6

325.87

C18H27NO2·HCl

>98% (HPLC)

Ethanol: 36 mg/mL (110.47 mM); Water: 6 mg/mL (18.41 mM); DMSO: 15 mg/mL (46.03 mM)

CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2.Cl

1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one;hydrochloride

(-20℃)

With Ice Pack

≥ 2 years