Optovin

Research use only, not for human use.

Optovin is a TRPA1 activator, which is reversibly photoactivated.

Optovin is a photoactive TRPA1 activator. Optovin activates human TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues. In animals with severed spinal cords, optovin treatment enables control of motor activity in the paralyzed extremities by localized illumination. These studies identify a light-based strategy for controlling endogenous TRPA1 receptors in vivo, with potential clinical and research applications in nontransgenic animals, including humans.

Optovin (1-10 μM) increases Zebrafish embryos motor activity greater than 40 standard deviations above the control mean at the photic stimuli, with an EC50 of 2 μM.Optovin (100 μM; 120 s) strongly activates 33% (35/105) of dorsal root ganglia (DRG) neurons.Optovin (10 μM; 1 min) activates HEK293T cells transfected with hTrpA1.

Optovin (1-10 μM) causes light-dependent motor excitation in vivo.Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice.Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish.

Optovin

Membrane Transporter/Ion Channel

Sodium Channel

TRPA1

Others-Field

——

348575-88-2

315.41

C15H13N3OS2

>98% (HPLC)

DMSO : ≥ 37 mg/mL; 117.31 mM

S1C(=S)NC(=O)/C/1=C\c1c(n(c(c1)C)c1cnccc1)C

(Z)-5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-2-thioxothiazolidin-4-one

(-20℃)

With Ice Pack

≥ 2 years