Cart
sales@molnova.com
Home - Products - Wnt/Notch/Hedgehog - Wnt/beta/catenin - Salinomycin

Salinomycin

CAS No. 53003-10-4

Salinomycin( AHR 3096 | AHR3096 | AHR-3096 | K 364 | Salinomycin | BioCox | Sacox | Salocin | Coxistac )

Catalog No. M14878 CAS No. 53003-10-4

Salinomycin is an inhibitor of Wnt/β-catenin signaling, which acts on the Wnt/Fzd/LRP complex.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 41 In Stock
5MG 67 In Stock
10MG 106 In Stock
25MG 197 In Stock
50MG 350 In Stock
100MG 502 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Salinomycin
  • Note
    Research use only, not for human use.
  • Brief Description
    Salinomycin is an inhibitor of Wnt/β-catenin signaling, which acts on the Wnt/Fzd/LRP complex.
  • Description
    Salinomycin is an inhibitor of Wnt/β-catenin signaling, which acts on the Wnt/Fzd/LRP complex. Salinomycin strongly suppresses Wnt1-stimulated reporter activity with an IC50 of 163 nM, and reduces β-catenin levels.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AHR 3096 | AHR3096 | AHR-3096 | K 364 | Salinomycin | BioCox | Sacox | Salocin | Coxistac
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Wnt/beta/catenin
  • Recptor
    IC50: 163 nM (Wnt1-stimulated reporter)
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    53003-10-4
  • Formula Weight
    751
  • Molecular Formula
    C??H??O??
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:≥ 36.7mg/mL In vivo: Add solvents to the product individually and in order: 10% DMSO+40% PEG300+5% Tween-80+45% saline (clear) ≥2mg/mL ；10% DMSO+90% corn oil (clear) ≥2mg/mL
  • SMILES
    CC[C@@H](C(O)=O)[C@H]1CC[C@@H]([C@H]([C@H]([C@@H]([C@@H](C([C@@H]([C@H]2O[C@]3([C@@H](C[C@@H]2C)C)O[C@]4([C@@H](C=C3)O)CC[C@](O4)([C@H]5CC[C@](CC)([C@@H](O5)C)O)C)CC)=O)C)O)C)O1)C
  • Chemical Name
    (R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7. 2. Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222(2):139-45.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • DIF-3

    DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins.

  • Phenibut

    Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice.

  • ICG-001

    ICG-001 is an antagonist of Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM.

Sign In Join Free