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Foxy-5
CAS No. 881188-51-8
Foxy-5( formyl-Met-Asp-Gly-Cys-Glu-Leu | Foxy5 )
Catalog No. M16389 CAS No. 881188-51-8
Foxy-5 is a novel Wnt-5A mimicking hexapeptide that inhibits breast cancer metastasis in vivo by targeting cell motility.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameFoxy-5
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NoteResearch use only, not for human use.
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Brief DescriptionFoxy-5 is a novel Wnt-5A mimicking hexapeptide that inhibits breast cancer metastasis in vivo by targeting cell motility.
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DescriptionFoxy-5 is a novel Wnt-5A mimicking hexapeptide that inhibits breast cancer metastasis in vivo by targeting cell motility; also significantly inhibits the initial metastatic dissemination of prostate cancer cells to regional and distal lymph nodes, specifically targets invasion without affecting apoptosis or viability of WNT5A-low prostate cancer cells. Breast Cancer Phase 1 Clinical.
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In Vitro——
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In VivoFoxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.Foxy-5 reduces the number of colonic cancer stem cells in a xenograft mouse model of human colonic cancer.
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Synonymsformyl-Met-Asp-Gly-Cys-Glu-Leu | Foxy5
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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RecptorWnt/beta/catenin
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number881188-51-8
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Formula Weight694.77
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Molecular FormulaC26H42N6O12S2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)C[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CS)NC(CNC([C@H](CC(O)=O)NC([C@H](CCSC)NC=O)=O)=O)=O)=O)=O
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Chemical Name(2S,5S,8R,14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecanedioic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. S?fholm A, et al. Clin Cancer Res. 2008 Oct 15;14(20):6556-63.
2. Ford CE, et al. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3919-24.
3. Canesin G, et al. PLoS One. 2017 Sep 8;12(9):e0184418.
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