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Adiphenine hydrochloride
CAS No. 50-42-0
Adiphenine hydrochloride( Adiphenine hydrochloride | NSC 129224 | NSC-129224 | NSC129224 )
Catalog No. M14716 CAS No. 50-42-0
Adiphenine hydrochloride is a nicotinic receptor inhibitor, used as an antispasmodic drug.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | 28 | In Stock |
|
| 500MG | 56 | In Stock |
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| 1G | 81 | In Stock |
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Biological Information
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Product NameAdiphenine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAdiphenine hydrochloride is a nicotinic receptor inhibitor, used as an antispasmodic drug.
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DescriptionAdiphenine hydrochloride is a nicotinic receptor inhibitor, used as an antispasmodic drug.(In Vitro):Adiphenine (10 nM-1 mM; 3 min) blocks the function of α1*-nAChR in a dose-dependent manner in TE671/RD cells, with an IC50 of 1.9 μM.Adiphenine (10 nM-1 mM; 3 min) blocks the function of α3α4*-nAChR in a dose-dependent manner in SH-SY5Y cells, with an IC50 of 1.8 μM.Adiphenine (10 nM-1 mM; 3 min) blocks the function of α4β2- and α4β4-nAChR in a dose-dependent manner in SH-EP1 cells, with IC50s of 3.7 and 6.3 μM, respectively.Adiphenine (50-200 μM; 30-60 s) decreases the frequency of ACh-induced single-channel currents in HEK 293 cells.(In Vivo):Adiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED50 of 62 mg/kg in mice.
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In VitroAdiphenine (10 nM-1 mM; 3 min) blocks the function of α1*-nAChR in a dose-dependent manner in TE671/RD cells, with an IC50 of 1.9 μM.Adiphenine (10 nM-1 mM; 3 min) blocks the function of α3α4*-nAChR in a dose-dependent manner in SH-SY5Y cells, with an IC50 of 1.8 μM.Adiphenine (10 nM-1 mM; 3 min) blocks the function of α4β2- and α4β4-nAChR in a dose-dependent manner in SH-EP1 cells, with IC50s of 3.7 and 6.3 μM, respectively.Adiphenine (50-200 μM; 30-60 s) decreases the frequency of ACh-induced single-channel currents in HEK 293 cells.
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In VivoAdiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED50 of 62 mg/kg in mice.
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SynonymsAdiphenine hydrochloride | NSC 129224 | NSC-129224 | NSC129224
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptorNicotinic Receptor
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number50-42-0
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Formula Weight347.88
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Molecular FormulaC20H25NO2·HCl
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Purity>98% (HPLC)
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SolubilityEthanol: 18 mg/mL (51.74 mM); Water: 70 mg/mL (201.21 mM); DMSO: 30 mg/mL (86.23 mM)
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SMILESO=C(OCCN(CC)CC)C(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl
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Chemical NameAcetic acid, diphenyl-, 2-(diethylamino)ethyl ester, hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Spitzmaul G, et al. Br J Pharmacol. 2009 Jul;157(5):804-17.
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