Cart
sales@molnova.com
Lonidamine
CAS No. 50264-69-2
Lonidamine( AF 1890 | DICA | Diclondazolic Acid )
Catalog No. M14699 CAS No. 50264-69-2
Lonidamine is an orally administered small molecule hexokinase inactivator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 2MG | 31 | In Stock |
|
| 5MG | 43 | In Stock |
|
| 10MG | 55 | In Stock |
|
| 25MG | 71 | In Stock |
|
| 50MG | 109 | In Stock |
|
| 100MG | 141 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 347 | In Stock |
|
| 1G | 516 | In Stock |
|
Biological Information
-
Product NameLonidamine
-
NoteResearch use only, not for human use.
-
Brief DescriptionLonidamine is an orally administered small molecule hexokinase inactivator.
-
DescriptionLonidamine is an orally administered small molecule hexokinase inactivator.(In Vitro):Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.(In Vivo):Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.
-
In VitroLonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.
-
In VivoLonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model. Animal Model:Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.Dosage:10, 30, 100 mg/kg/day Administration:Oral administration, daily, d10 to d20 after BLM treatment.Result:Partially or completely reversed the increases in HK2 and lactate induced by BLM and reduced the expression of 10 profibrotic mediators.
-
SynonymsAF 1890 | DICA | Diclondazolic Acid
-
PathwayOthers
-
TargetOther Targets
-
Recptorhexokinase
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number50264-69-2
-
Formula Weight321.17
-
Molecular FormulaC15H10Cl2N2O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: 64 mg/mL (199.27 mM)
-
SMILESO=C(C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3)O
-
Chemical Name1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
RIG012
RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 μM (measured by NADH-coupled ATPase), and it inhibits the expression of IFN-β and ISG hRsad2.
-
34-Dihydroxyflavone
34-Dihydroxyflavone Acts as an Antioxidant and Antiapoptotic Agent .
-
Ocimene
Beta-Ocimene is a naturally occurring organic compound that belongs to the terpene family. It exists as a mixture of three isomers: cis β-Ocimene, trans β-Ocimene and myrcene-like β-Ocimene. It has a pleasant, sweet herbaceous scent and is found in many plants, including mint, basil, parsley, and kumquat. β-Ocimene is widely used in the flavor and fragrance industry due to its characteristic aroma and taste. It also has potential applications in agriculture as natural insect repellants and pheromones that attract beneficial insects. β-Ocimene has potential anti-inflammatory and anticancer activities.
