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Hinokitiol
CAS No. 499-44-5
Hinokitiol( 4-Isopropyltropolone | β-Thujaplicin )
Catalog No. M14672 CAS No. 499-44-5
Hinokitiol (4-Isopropyltropolone;β-Thujaplicin) is a tropolone-related natural compound that can induces apoptosis and cell cycle arrest.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 27 | In Stock |
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| 50MG | 38 | In Stock |
|
| 100MG | 67 | In Stock |
|
| 200MG | 87 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameHinokitiol
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NoteResearch use only, not for human use.
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Brief DescriptionHinokitiol (4-Isopropyltropolone;β-Thujaplicin) is a tropolone-related natural compound that can induces apoptosis and cell cycle arrest.
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DescriptionHinokitiol (4-Isopropyltropolone;β-Thujaplicin) is a tropolone-related natural compound that can induces apoptosis and cell cycle arrest, exhibits anti-inflammatory and anti-tumor activities; inhibits the proliferation of Chlamydia trachomatis with MIC of 32 ug/mL; also can harness such gradients to restore iron transport into, within, and/or out of cells.
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In VitroIn U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC50 values of 316.5 ± 35.5 and 152.5 ± 25.3 μM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression of MGMT, CHST10, and BTG4 genes.
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In Vivo——
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Synonyms4-Isopropyltropolone | β-Thujaplicin
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PathwayApoptosis
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TargetApoptosis
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RecptorERα
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number499-44-5
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Formula Weight164.204
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Molecular FormulaC10H12O2
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Purity>98% (HPLC)
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SolubilityChloroform: Soluble DMSO: 29 mg/mL (176.6 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESCC(C)C1=CC(=O)C(=CC=C1)O
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Chemical Name2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Clovamide
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