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Hinokitiol

CAS No. 499-44-5

Hinokitiol( 4-Isopropyltropolone | β-Thujaplicin )

Catalog No. M14672 CAS No. 499-44-5

Hinokitiol (4-Isopropyltropolone;β-Thujaplicin) is a tropolone-related natural compound that can induces apoptosis and cell cycle arrest.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 33 In Stock
50MG 29 In Stock
100MG 52 In Stock
200MG Get Quote In Stock
500MG 75 In Stock
1G 91 In Stock
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Biological Information

  • Product Name
    Hinokitiol
  • Note
    Research use only, not for human use.
  • Brief Description
    Hinokitiol (4-Isopropyltropolone;β-Thujaplicin) is a tropolone-related natural compound that can induces apoptosis and cell cycle arrest.
  • Description
    Hinokitiol (4-Isopropyltropolone;β-Thujaplicin) is a tropolone-related natural compound that can induces apoptosis and cell cycle arrest, exhibits anti-inflammatory and anti-tumor activities; inhibits the proliferation of Chlamydia trachomatis with MIC of 32 ug/mL; also can harness such gradients to restore iron transport into, within, and/or out of cells.
  • In Vitro
    In U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC50 values of 316.5 ± 35.5 and 152.5 ± 25.3 μM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression of MGMT, CHST10, and BTG4 genes.
  • In Vivo
    ——
  • Synonyms
    4-Isopropyltropolone | β-Thujaplicin
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    ERα
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    499-44-5
  • Formula Weight
    164.204
  • Molecular Formula
    C10H12O2
  • Purity
    >98% (HPLC)
  • Solubility
    Chloroform: Soluble DMSO: 29 mg/mL (176.6 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    CC(C)C1=CC(=O)C(=CC=C1)O
  • Chemical Name
    2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yamano H, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2519-21. 2. Seo JS, et al. BMC Cell Biol. 2017 Feb 27;18(1):14. 3. Grillo AS, et al. Science. 2017 May 12;356(6338):608-616.
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