Iberin

Research use only, not for human use.

Iberin is an isothiocyanate compound from horseradish that exhibits anticancer activity.

Iberin is an isothiocyanate compound from horseradish that exhibits anticancer activity, a quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa, and significantly induces Nrf2 nuclear translocation in NIH3T3 fibroblasts; induces cell cycle arrest and apoptosis in human neuroblastoma cells associated with inhibition of expression of Cdk2, Cdk4, and Cdk6 proteins.

Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9.

Iberin is tested in an in vivo foreign-body infection mouse model, and the results show no significantly difference in bacterial clearance between treated and nontreated miced. Iberin increases tissue levels of the phase II detoxification enzymes quinone reductase and glutathione S-transferase in a variety of rat tissues.

NSC 321801

Apoptosis

Apoptosis

Apoptosis

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505-44-2

163.26106

C5H9NOS2

>98% (HPLC)

Ethanol: 10 mg/mL

S=C=NCCCS(C)=O

Propane, 1-isothiocyanato-3-(methylsulfinyl)-

(-20℃)

With Ice Pack

≥ 2 years