(+)-Bicuculline( NSC 32192 )

Catalog No. M14624 CAS No. 485-49-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

(+)-Bicuculline
Note

Research use only, not for human use.
Brief Description

Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.
Description

Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.
In Vitro

——
In Vivo

——
Synonyms

NSC 32192
Pathway

Membrane Transporter/Ion Channel
Target

GAT
Recptor

GABAR
Research Area

Other Indications
Indication

——

CAS Number

485-49-4
Formula Weight

367.36
Molecular Formula

C20H17NO6
Purity

>98% (HPLC)
Solubility

DMSO: 73 mg/mL warmed (198.72 mM)
SMILES

O=C1O[C@@H]([C@H]2N(C)CCC3=CC4=C(OCO4)C=C23)C5=CC=C(OCO6)C6=C51
Chemical Name

(R)-6-((S)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one

1. Huang SH, et al. Eur J Pharmacol, 2003, 464(1), 1-8.

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