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Bufalin
CAS No. 465-21-4
Bufalin( NSC 89595 )
Catalog No. M14561 CAS No. 465-21-4
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | In Stock |
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| 10MG | 72 | In Stock |
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| 25MG | 120 | In Stock |
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| 50MG | 177 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBufalin
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NoteResearch use only, not for human use.
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Brief DescriptionBufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu.
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DescriptionBufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.
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In VitroCell Viability Assay Cell Line:NCI-H460 cells Concentration:0, 1, 2, 4 μM Incubation Time:48 hours Result:Decreased viability of NCI-H460 cells in a dose-dependent manner.
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In VivoAnimal Model:Forty male athymic BALB/c nu/nu mice (6-8 weeks old)Dosage:0.1, 0.2, or 0.4 mg/kg Administration:I.P. every day until 14 days Result:Dose-dependently suppressed tumor growth.
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SynonymsNSC 89595
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PathwayEndocrinology/Hormones
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TargetATPase
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RecptorNa+/K+-ATPase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number465-21-4
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Formula Weight386.52
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Molecular FormulaC24H34O4
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILES5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
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Chemical Name5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Goniothalamin
Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines, can induce cytotoxicity and apoptosis on RT4 cells, induce apoptosis on HepG2 liver cancer cells via induction of caspase-3 with less sensitivity on the cell line of Chang cells.
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Mtb ATP synthase-IN-...
Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.
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Bacoside A3
Bacoside A3 is one of the components of Bacopa monnieri (L.) Wettst. bacoside A with antioxidant potential. Bacoside A3 shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.
