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HR22C16
CAS No. 462630-41-7
HR22C16( Monastroline )
Catalog No. M14558 CAS No. 462630-41-7
A potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameHR22C16
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM.
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DescriptionA potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins; inhibits cell survival in both Taxol-sensitive and -resistant ovarian cancer cells with at least 15-fold greater efficacy than monastrol.
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In Vitro——
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In Vivo——
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SynonymsMonastroline
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetKinesin
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RecptorKinesin
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Research Area——
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Indication——
Chemical Information
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CAS Number462630-41-7
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Formula Weight389.455
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Molecular FormulaC23H23N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1CC2=C(C(C3=CC=CC(O)=C3)N14)NC5=C2C=CC=C5)N(CCCC)C4=O
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Chemical Name2-butyl-5-(3-hydroxyphenyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hotha S, et al. Angew Chem Int Ed Engl. 2003 May 30;42(21):2379-82.
2. Marcus AI, et al. J Biol Chem. 2005 Mar 25;280(12):11569-77.
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