DT204( DT-204 | DT 204 )

Catalog No. M14453 CAS No. 428497-71-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

DT204
Note

Research use only, not for human use.
Brief Description

DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis.
Description

DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis; stablizes and increases p27 levels, does not increase the level of p53, demonstrates potential synergy with CI values of 0.7, 0.8 and 0.7 for RPMI8226, U266 and MM1.S respectively combined with 1 nM BTZ, co-treatment induces apoptosis in cells resistant to the proteasome inhibitors BTZ, carfilzomib or ixazomib; overcomes drug resistance and reduces the in vivo growth of myeloma tumors in murine models.
In Vitro

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In Vivo

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Synonyms

DT-204 | DT 204
Pathway

Proteasome/Ubiquitin
Target

E3 Ubiquitin Ligase
Recptor

E3 Ubiquitin Ligase
Research Area

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Indication

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CAS Number

428497-71-6
Formula Weight

482.729
Molecular Formula

C19H13BrClNO5S
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(O)COC1=CC=C(Br)C=C1/C=C(SC(N2CC3=CC=C(Cl)C=C3)=O)/C2=O
Chemical Name

2-(4-bromo-2-((3-(4-chlorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid

1. Malek E, et al. Leukemia. 2017 Mar;31(3):645-653.

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