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Heclin

CAS No. 890605-54-6

Heclin( Heclin | )

Catalog No. M16428 CAS No. 890605-54-6

A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	67	In Stock
2MG	34	In Stock
5MG	61	In Stock
10MG	107	In Stock
25MG	188	In Stock
50MG	299	In Stock
100MG	477	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Heclin
Note

Research use only, not for human use.
Brief Description

A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.
Description

A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally.
In Vitro

Western Blot Analysis Cell Line:BGC803 and MKN45 cells Concentration:10 μM Incubation Time:48 h Result:Reduced phosphorylation of Akt.
In Vivo

——
Synonyms

Heclin |
Pathway

Proteasome/Ubiquitin
Target

E3 Ubiquitin Ligase
Recptor

E3 Ubiquitin Ligase
Research Area

——
Indication

——

Chemical Information

CAS Number

890605-54-6
Formula Weight

283.32
Molecular Formula

C17H17NO3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (352.96 mM)
SMILES

O=C(NC1=CC=C(C(C)=O)C=C1)/C=C/C2=CC=C(CC)O2
Chemical Name

N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Mund T, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41.

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