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Heclin
CAS No. 890605-54-6
Heclin( Heclin | )
Catalog No. M16428 CAS No. 890605-54-6
A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 2MG | 34 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 299 | In Stock |
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| 100MG | 477 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHeclin
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.
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DescriptionA small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally.
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In VitroWestern Blot Analysis Cell Line:BGC803 and MKN45 cells Concentration:10 μM Incubation Time:48 h Result:Reduced phosphorylation of Akt.
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In Vivo——
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SynonymsHeclin |
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PathwayProteasome/Ubiquitin
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TargetE3 Ubiquitin Ligase
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RecptorE3 Ubiquitin Ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number890605-54-6
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Formula Weight283.32
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Molecular FormulaC17H17NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (352.96 mM)
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SMILESO=C(NC1=CC=C(C(C)=O)C=C1)/C=C/C2=CC=C(CC)O2
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Chemical NameN-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mund T, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41.
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