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Telaprevir

CAS No. 402957-28-2

Telaprevir( VX-950 | VX950 | VX 950 )

Catalog No. M14381 CAS No. 402957-28-2

A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 170 In Stock
5MG 92 In Stock
10MG 154 In Stock
25MG 246 In Stock
50MG 333 In Stock
100MG 611 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Telaprevir
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM.
  • Description
    A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM; demonstrates excellent antiviral activity both in genotype 1b HCV replicon cells (IC50=354 nM) and in human fetal hepatocytes (IC50=280 nM); shows excellent viral inhibition in vivo with favorable pharmacokinetic profile.HCV Infection Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    VX-950 | VX950 | VX 950
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCVNS3-4Aserineprotease
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    402957-28-2
  • Formula Weight
    679.8493
  • Molecular Formula
    C36H53N7O6
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C([C@@H]1[C@](CCC2)([H])[C@]2([H])CN1C([C@@H](NC([C@H](C3CCCCC3)NC(C4=NC=CN=C4)=O)=O)C(C)(C)C)=O)N[C@@H](CCC)C(C(NC5CC5)=O)=O
  • Chemical Name
    Cyclopenta[c]pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydro-, (1S,3aR,6aS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Perni RB, et al. Antimicrob Agents Chemother. 2006 Mar;50(3):899-909. 2. Lin C, et al. J Biol Chem. 2004 Apr 23;279(17):17508-14. 3. Lin C, et al. J Biol Chem. 2005 Nov 4;280(44):36784-91.
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