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NM107

CAS No. 20724-73-6

NM107( 2'-C-Methylcytidine | NM-107 | Valopicitabine )

Catalog No. M13224 CAS No. 20724-73-6

A nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 59 In Stock
2MG 33 In Stock
5MG 54 In Stock
10MG 73 In Stock
25MG 113 In Stock
50MG 146 In Stock
100MG 182 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    NM107
  • Note
    Research use only, not for human use.
  • Brief Description
    A nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells.
  • Description
    A nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells; The active component of NM283.HCV Infection Phase 2 Discontinued.
  • In Vitro
    RT-PCR Cell Line:Huh7-1 cells and cell culture-propagated HCV (HCVcc)Concentration:25 μM Incubation Time:24 hours Result:Extracellular virus titers declined in parallel with intracellular RNA levels.
  • In Vivo
    ——
  • Synonyms
    2'-C-Methylcytidine | NM-107 | Valopicitabine
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCV
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    20724-73-6
  • Formula Weight
    257.2432
  • Molecular Formula
    C10H15N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    OC[C@@H]1[C@H]([C@@]([C@H](N2C(N=C(C=C2)N)=O)O1)(C)O)O
  • Chemical Name
    Cytidine, 2'-C-methyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gardelli C, et al. J Med Chem. 2009 Sep 10;52(17):5394-407. 2. McCown MF, et al. Antimicrob Agents Chemother. 2008 May;52(5):1604-12.
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