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RBC8
CAS No. 361185-42-4
RBC8( RBC8 | RBC-8 | RBC 8 )
Catalog No. M17494 CAS No. 361185-42-4
RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
|
| 5MG | 88 | In Stock |
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| 10MG | 150 | In Stock |
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| 25MG | 297 | In Stock |
|
| 50MG | 461 | In Stock |
|
| 100MG | 672 | In Stock |
|
| 200MG | 918 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRBC8
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NoteResearch use only, not for human use.
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Brief DescriptionRBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.
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DescriptionRBC8 is a RalA and RalB GTPase inhibitor (EC50 ~3.5 μM). RBC8 suppresses growth of xenograft tumors in mice. e Ras-like GTPases RalA and RalB are important drivers of tumour growth and metastasis. Chemicals that block Ral function would be valuable as research tools and for cancer therapeutics.
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In Vitro——
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In Vivo——
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SynonymsRBC8 | RBC-8 | RBC 8
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorGTPases RalA| GTPases RalB
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number361185-42-4
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Formula Weight424.45
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Molecular FormulaC25H20N4O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 40 mg/mL; 94.24 mM
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SMILESCOc1ccc(c(c1)C1C(=C(N)Oc2c1c(c1ccc3ccccc3c1)[nH]n2)C#N)OC
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Chemical Name6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yan C, et al. Nature. 2014, 515(7527), 443-447.
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