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LY-364947
CAS No. 396129-53-6
LY-364947( HTS 466284 | TGF-β RI Kinase Inhibitor )
Catalog No. M14364 CAS No. 396129-53-6
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 63 | In Stock |
|
| 5MG | 56 | In Stock |
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| 10MG | 71 | In Stock |
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| 25MG | 139 | In Stock |
|
| 50MG | 249 | In Stock |
|
| 100MG | 365 | In Stock |
|
| 200MG | 548 | In Stock |
|
| 500MG | 858 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY-364947
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NoteResearch use only, not for human use.
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Brief DescriptionLY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.
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DescriptionLY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.
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In Vitro——
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In Vivo——
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SynonymsHTS 466284 | TGF-β RI Kinase Inhibitor
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorCK1δ| MLK-7K| TGFβRI| TGFβRII| RIPK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number396129-53-6
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Formula Weight272.3
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Molecular FormulaC17H12N4
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Purity>98% (HPLC)
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SolubilityDMSO: 1 mg/mL (3.67 mM)
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SMILESC1(C2=CNN=C2C3=NC=CC=C3)=CC=NC4=CC=CC=C14
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Chemical Name4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)quinoline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li HY, et al. J Med Chem, 2006, 49(6), 2138-2142.
molnova catalog
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