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LY-364947

CAS No. 396129-53-6

LY-364947( HTS 466284 | TGF-β RI Kinase Inhibitor )

Catalog No. M14364 CAS No. 396129-53-6

LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	63	In Stock
5MG	56	In Stock
10MG	71	In Stock
25MG	139	In Stock
50MG	249	In Stock
100MG	365	In Stock
200MG	548	In Stock
500MG	858	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

LY-364947
Note

Research use only, not for human use.
Brief Description

LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.
Description

LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.
In Vitro

——
In Vivo

——
Synonyms

HTS 466284 | TGF-β RI Kinase Inhibitor
Pathway

Metabolic Enzyme/Protease
Target

Casein Kinase
Recptor

CK1δ| MLK-7K| TGFβRI| TGFβRII| RIPK2
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

396129-53-6
Formula Weight

272.3
Molecular Formula

C17H12N4
Purity

>98% (HPLC)
Solubility

DMSO: 1 mg/mL (3.67 mM)
SMILES

C1(C2=CNN=C2C3=NC=CC=C3)=CC=NC4=CC=CC=C14
Chemical Name

4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)quinoline

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Li HY, et al. J Med Chem, 2006, 49(6), 2138-2142.

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