TA-01( TA01 | TA 01 )

Catalog No. M12689 CAS No. 1784751-18-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TA-01
Note

Research use only, not for human use.
Brief Description

A potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively.
Description

A potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively; inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis, and increases ATF-2 and MEF2C during cardiac differentiation.
In Vitro

TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 (5 μM) is not cytotoxic, completely inhibits cardiogenesis, but induces cardiogenesis at lower concentration.
In Vivo

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Synonyms

TA01 | TA 01
Pathway

Metabolic Enzyme/Protease
Target

Casein Kinase
Recptor

CKIδ|CKI?|p38MAPkinase
Research Area

Other Indications
Indication

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CAS Number

1784751-18-3
Formula Weight

351.3246
Molecular Formula

C20H12F3N3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

FC1=CC=CC=C1C2=C(C3=CC=NC=C3)NC(C4=C(F)C=CC=C4F)=N2
Chemical Name

Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-

1. Laco F, et al. J Mol Cell Cardiol. 2015 Mar;80:56-70.

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