FPFT-2216

CAS No. 2367619-87-0

FPFT-2216( —— )

Catalog No. M35444 CAS No. 2367619-87-0

FPFT-2216 is a molecular gel that degrades IKZF6, IKZF1, DE1D, and CK3α.FPFT-2216 has potential antitumor activity and can be used to study diseases of the immune system.FPFT-2216 is a molecular gel that degrades IKZF6, IKZF1, DE1D, and CK3α.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 250 In Stock
5MG 235 In Stock
10MG 353 In Stock
25MG 748 In Stock
50MG 1144 In Stock
100MG 1841 In Stock
200MG 2492 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    FPFT-2216
  • Note
    Research use only, not for human use.
  • Brief Description
    FPFT-2216 is a molecular gel that degrades IKZF6, IKZF1, DE1D, and CK3α.FPFT-2216 has potential antitumor activity and can be used to study diseases of the immune system.FPFT-2216 is a molecular gel that degrades IKZF6, IKZF1, DE1D, and CK3α.
  • Description
    FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease.
  • In Vitro
    Western Blot Analysis Cell Line:MOLT4 cells Concentration:1 μM Incubation Time:0 h, 2 h, 4 h, 6 h, 16 h, 24 h Result:Showed complete degradation of PDE6D within 2 h, and the degradation of PDE6D persisted for at least 24 h.Western Blot Analysis Cell Line:MOLT4 cells Concentration:0 nM, 1.6 nM, 8 nM, 40 nM, 200 nM, 1 μM Incubation Time: 4 h Result:Exhibited over 50% degradation of PDE6D at a dose of 8 nM, while maximum degradation of PDE6D along with IKZF1, IKZF3, and CK1α at a dose of 200 nM.
  • In Vivo
    Animal Model:CRBNI391V mice Dosage:30 mg/kg (solubilized in 0.5% carboxymethyl cellulose/sodium and 0.25% Tween 80) Administration:p.o. or i.p.Result:Induced significant degradation of CK-1α, and IKZF1.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Casein Kinase
  • Recptor
    Casein Kinase | Molecular Glues | PDE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2367619-87-0
  • Formula Weight
    292.31
  • Molecular Formula
    C12H12N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (342.10 mM; Ultrasonic )
  • SMILES
    COc1cscc1-c1cn(nn1)C1CCC(=O)NC1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.?
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