Cart
sales@molnova.com
Perampanel
CAS No. 380917-97-5
Perampanel( E2007 | E 2007 )
Catalog No. M14317 CAS No. 380917-97-5
Perampanel (E2007) is a novel, orally active, noncompetitive AMPA receptor (AMPAR) antagonist with IC50 of 93 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePerampanel
-
NoteResearch use only, not for human use.
-
Brief DescriptionPerampanel (E2007) is a novel, orally active, noncompetitive AMPA receptor (AMPAR) antagonist with IC50 of 93 nM.
-
DescriptionPerampanel (E2007) is a novel, orally active, noncompetitive AMPA receptor (AMPAR) antagonist with IC50 of 93 nM; inhibits AMPA-induced increases in Ca2+(i) with minimal effect on NMDA-induced Ca2+(i); reduces seizure activity in rodent models of epilepsy.Epilepsy Approved.
-
In Vitro——
-
In Vivo——
-
SynonymsE2007 | E 2007
-
PathwayMembrane Transporter/Ion Channel
-
TargetiGluR
-
RecptoriGluR
-
Research AreaNeurological Disease
-
IndicationEpilepsy
Chemical Information
-
CAS Number380917-97-5
-
Formula Weight349.384
-
Molecular FormulaC23H15N3O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1C(C2=CC=CC=C2C#N)=CC(C3=NC=CC=C3)=CN1C4=CC=CC=C4
-
Chemical Name2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-benzonitrile
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hanada T, et al. Epilepsia. 2011 Jul;52(7):1331-40.
2. Ceolin L, et al. Neurochem Int. 2012 Sep;61(4):517-22.
3. Lees A, et al. Mov Disord. 2012 Feb;27(2):284-8.
molnova catalog
related products
-
Org-26576
A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516.
-
AMPA receptor antago...
AMPA receptor antagonist-2 is an AMPA receptor antagonist.
-
NS-1209
A selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM; display selectivity for the [3H] AMPA over the [3H]kainate- (IC50=81 uM), [3H]CGS19755, and [3H]glycine-binding sites (IC50 > 30 uM) in rat cortical membranes.
