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NNC 55-0396
CAS No. 357400-13-6
NNC 55-0396( NNC 55-0396 dihydrochloride )
Catalog No. M14227 CAS No. 357400-13-6
A potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 155 | In Stock |
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| 5MG | 122 | In Stock |
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| 10MG | 202 | In Stock |
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| 25MG | 354 | In Stock |
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| 50MG | 538 | In Stock |
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| 100MG | 770 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNNC 55-0396
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM.
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DescriptionA potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM; has no detectable effect on high-voltage-activated channels in INS-1 cells; inhibits MCF-7 (ERalpha+) cellular proliferation, inhibits tumor-induced angiogenesis in vitro and in vivo by suppressing HIF-1α stability; significantly suppresses glioblastoma tumor growth in a xenograft model.
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In Vitro——
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In VivoAnimal Model:GABAA receptor α1 subunit null mouse model Dosage:20 mg/kg Administration:Intraperitoneal injection; 20 mg/kg, once Result:Suppressed tremor in GABAA subunit α1-null mice.
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SynonymsNNC 55-0396 dihydrochloride
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number357400-13-6
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Formula Weight564.5619
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Molecular FormulaC30H40Cl2FN3O2
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESCC(C)C1C2=C(CCC1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)C5CC5)C=C(C=C2)F.Cl.Cl
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Chemical NameCyclopropanecarboxylic acid, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, hydrochloride (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huang L, et al. J Pharmacol Exp Ther. 2004 Apr;309(1):193-9.
2. Taylor JT, et al. Cancer Lett. 2008 Aug 18;267(1):116-24.
3. Kim KH, et al. J Mol Med (Berl). 2015 May;93(5):499-509.
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