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Home - Products - Apoptosis - MDM2-p53 - MS7972

MS7972

CAS No. 352553-42-5

MS7972( MS 7972 )

Catalog No. M14203 CAS No. 352553-42-5

MS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MS7972
  • Note
    Research use only, not for human use.
  • Brief Description
    MS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association.
  • Description
    MS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association; completely blocks CBP BRD/p53-AcK382 interactions at 50 uM, results in loss of p53 phosphorylation at Ser15 as well as acetylation at Lys382; causes a dramatic decrease of the doxorubicin-induced p53 increase in U2OS cells.
  • In Vitro
    Addition of MS7972 to the CBP BRD results in emission at 445 nm and quenching of the CBP BRD due to resonance energy transfer.
  • In Vivo
    ——
  • Synonyms
    MS 7972
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    MDM2-p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    352553-42-5
  • Formula Weight
    227.263
  • Molecular Formula
    C14H13NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (440.02 mM)
  • SMILES
    O=C1C(N(C(C)=O)C2=C3C=CC=C2)=C3CCC1
  • Chemical Name
    9-Acetyl-3,4-dihydro-2H-carbazol-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sachchidanand, et al. Chem Biol. 2006 Jan;13(1):81-90.
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