Cart
sales@molnova.com
HL001
CAS No. 1186371-31-2
HL001( HL 001 )
Catalog No. M10634 CAS No. 1186371-31-2
HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameHL001
-
NoteResearch use only, not for human use.
-
Brief DescriptionHL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM.
-
DescriptionHL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression; stabilizes p53 through inhibiting the MDM2-mediated p53 ubiquitination, and downregulates G3BP1 and induces ROS and DNA damage; selectively suppresses tumor growth in p53 wild-type NSCLC harboring p53-72R through disrupting interaction between MDM2 and p53-72R in a CypA-dependent manner; synergistically enhance tumor regression in orthotopic NSCLC mouse model combined with cisplatin.
-
In Vitro——
-
In Vivo——
-
SynonymsHL 001
-
PathwayApoptosis
-
TargetMDM2-p53
-
RecptorMDM2-p53
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1186371-31-2
-
Formula Weight360.369
-
Molecular FormulaC21H16N2O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical NameN-((9H-fluoren-9-yl)carbamoyl)-2,6-dihydroxybenzamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lu W, et al. Oncogene. 2017 Aug 17;36(33):4719-4731.
2. Ni S, et al. J Med Chem. 2009 Sep 10;52(17):5295-8.
molnova catalog
related products
-
PK-11007
A 2-sulfonylpyrimidine compound that is a mild thiol alkylator with anticancer activity toward p53-compromised cells.
-
SCH 529074
SCH 529074 is a small molecule mutant p53 reactivator that binds p53 DNA binding domain with Kd of 1-2 uM.
-
PhiKan 083
PhiKan 083 is a carbazole derivative PhiKan 083 reduces the cell viability of engineered variants of Ln229 cells, in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells.
