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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - BMS-394136

BMS-394136

CAS No. 343246-73-1

BMS-394136( BMS394136 )

Catalog No. M14168 CAS No. 343246-73-1

BMS-394136 is a potent, selective IKur/Kv1.5inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BMS-394136
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-394136 is a potent, selective IKur/Kv1.5inhibitor.
  • Description
    BMS-394136 is a potent, selective IKur/Kv1.5inhibitor, increases atrial action potential duration (APD) and prolongs AERP but not VERP in both rabbits and beagles.Heart Arrhythmia Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BMS394136
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    343246-73-1
  • Formula Weight
    471.357
  • Molecular Formula
    C24H21Cl2FN4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C([C@H](n2c(ccn2)N1)c3ccc(c(c3)Cl)Cl)C(=O)N4CCC[C@H]4c5ccc(cc5)F
  • Chemical Name
    Pyrrolidine, 1-[[(7R)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluorophenyl)-, (2S)- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dezhi Xing, et al. Abstract 2515: A Selective IKur Blocker, BMS-394136 Selectively Prolongs Atrial APD and Refractoriness in Beagles and Rabbits. Circulation. 2009;120:S654.
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