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HIV-1 inhibitor 18A
CAS No. 331261-50-8
HIV-1 inhibitor 18A( Compound 18A )
Catalog No. M14111 CAS No. 331261-50-8
HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 218 | In Stock |
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| 5MG | 227 | In Stock |
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| 10MG | 313 | In Stock |
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| 25MG | 535 | In Stock |
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| 50MG | 736 | In Stock |
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| 100MG | 1042 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHIV-1 inhibitor 18A
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NoteResearch use only, not for human use.
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Brief DescriptionHIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry.
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DescriptionHIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM; inhibits the CD4-induced disruption of quaternary structures at the trimer apex and the exposure of the gp41 HR1 coiled coil, does not interfere with CD4 or CCR5 binding.
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In VitroCell Viability Assay Cell Line:PBMCs Concentration:0.01-10 μM Incubation Time:40-44 h Result:Inhibited infection of HIV-1JR-FL, with an IC50 value of 0.4 μM.
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In Vivo——
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SynonymsCompound 18A
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research Area——
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Indication——
Chemical Information
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CAS Number331261-50-8
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Formula Weight313.33
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Molecular FormulaC14H11N5O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N/N=C/C1=CC=C(O)C=C1)NC2=CC=CC3=NSN=C32
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Chemical NameN-2,1,3-Benzothiadiazol-4-yl-2-[(4-hydroxyphenyl)methylene]-hydrazinecarboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Herschhorn A, et al. Nat Chem Biol. 2014 Oct;10(10):845-52.
2. Berinyuy E, et al. J Recept Signal Transduct Res. 2016;36(2):119-29.
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