Moroxydine hydrochloride

Research use only, not for human use.

Moroxydine hydrochloride is a synthetic antiviral drug chemically belonging to the series of the heterocyclic biguanidines. Structurally moroxydine is a heterocyclic biguanidine.

Moroxydine hydrochloride is a synthetic antiviral drug chemically belonging to the series of the heterocyclic biguanidines. Structurally moroxydine is a heterocyclic biguanidine. It possesses antiviral activity and is of value in the prevention and treatment of influenza. Although its mechanism of action is not fully known the effects seem to be due to an influence on the virus host-cell system.

Cell Viability Assay Cell Line:GCRV infected CIK cells Concentration:1.0, 2.5, 6.3, 15.9, 39.8, 100 μg/mL.Incubation Time:24, 48, 72, 96 hResult:Showed concentration- and time-dependent induction of cell viability.Apoptosis Analysis Cell Line:GCRV infected CIK cells Concentration:40 μg/mL.Incubation Time:48, 96 h Result:Could block the virus-induced CPE and cell death within 96 h.Western Blot Analysis Cell Line:GCRV infected CIK cells Concentration:40 μg/mL Incubation Time:12, 24, 48 h Result:Completely avoided the apoptosis and also significantly inhibited the caspase 3 activity, Bax expression and down-regulated Bcl-2 at 48 h, compared with GCRV infection group.

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ABOB

Immunology/Inflammation

Antiviral

DNA viruses| RNA viruses

Infection

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3160-91-6

207.66

C6H13N5O·HCl

>98% (HPLC)

Water: 42 mg/mL (202.25 mM); DMSO: 42 mg/mL (202.25 mM)

N1(C(=N)NC(N)=N)CCOCC1

4-Morpholinecarboximidoylguanidine

(-20℃)

With Ice Pack

≥ 2 years