Deltarasin( —— )

Catalog No. M17298 CAS No. 1440898-61-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Deltarasin
Note

Research use only, not for human use.
Brief Description

Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
Description

Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
In Vitro

In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with Kd?of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.
In Vivo

Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts.
Synonyms

——
Pathway

Immunology/Inflammation
Target

Antiviral
Recptor

PDEδ
Research Area

Cancer
Indication

——

CAS Number

1440898-61-2
Formula Weight

603.75
Molecular Formula

C40H37N5O
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 42 mg/mL. 69.57 mM
SMILES

C(OC1=CC=C(C=C1)C1=NC2=C(C=CC=C2)N1CC1=CC=CC=C1)[C@H](C1CCNCC1)N1C2=CC=CC=C2N=C1C1=CC=CC=C1
Chemical Name

——

1. Zimmermann G, et al. Nature. 2013, 497(7451), 638-642.

Calculator

molnova catalog