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STF-62247
CAS No. 315702-99-9
STF-62247( STF62247 | STF 62247 )
Catalog No. M14025 CAS No. 315702-99-9
STF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 56 | In Stock |
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| 50MG | 95 | In Stock |
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| 100MG | 166 | In Stock |
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| 200MG | 254 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSTF-62247
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NoteResearch use only, not for human use.
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Brief DescriptionSTF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells.
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DescriptionSTF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells; induces cytotoxicity and reduces tumor growth in VHL-deficient cells in a HIF-independent manner, PI3K and Golgi trafficking are required as initial signals in STF-62247-induced autophagy.Kidney Cancer Preclinical.
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In VitroIn RCC4, RCC4/VHL, SN12C, SN12C-VHL shRNA cells, STF-62247 (0-30 μM) is selectively toxic to VHL-deficient cells compared to their VHL wild-type counterparts.STF-62247-treated cells accumulated intracytoplasmic vacuoles characteristic of cells undergoing autophagy. Moreover, these vacuoles are larger in VHL-deficient RCC4 and SN12C-VHL shRNA cells than in wild-type VHL cells.
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In VivoSTF-62247 (2.7-8 mg/kg; intraperitoneal injection; daily; for 9 days) treatment significantly reduces tumor growth of VHL-deficient cells. Animal Model:SCID mice implanted with SN12C-VHL shRNA cells Dosage:2.7 mg/kg, or 8 mg/kg Administration:Intraperitoneal injection; daily; for 9 days Result:Significantly reduced tumor growth of VHL-deficient cells.
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SynonymsSTF62247 | STF 62247
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PathwayAutophagy
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TargetAutophagy
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RecptorER
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Research AreaCancer
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IndicationKidney Cancer
Chemical Information
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CAS Number315702-99-9
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Formula Weight267.3488
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Molecular FormulaC15H13N3S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 31 mg/mL
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SMILESCC1=CC(NC2=NC(C3=CC=NC=C3)=CS2)=CC=C1
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Chemical Name2-Thiazolamine, N-(3-methylphenyl)-4-(4-pyridinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Turcotte S, et al. Cancer Cell. 2008 Jul 8;14(1):90-102.
2. Turcotte S, et al. Autophagy. 2008 Oct;4(7):944-6.
3. Chan DA, et al. Cell Cycle. 2008 Oct;7(19):2987-90.
4.?Kozako T, et al. Oncotarget. 2018 Jun 12;9(45):27645-27655.
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