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Thonzonium Bromide
CAS No. 553-08-2
Thonzonium Bromide( —— )
Catalog No. M15007 CAS No. 553-08-2
Thonzonium bromide is a monocationic detergent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 49 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 45 | In Stock |
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| 25MG | 89 | In Stock |
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| 50MG | 166 | In Stock |
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| 100MG | 249 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 617 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameThonzonium Bromide
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NoteResearch use only, not for human use.
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Brief DescriptionThonzonium bromide is a monocationic detergent.
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DescriptionThonzonium bromide is a monocationic detergent.(In Vitro):Thonzonium bromide inhibits RANKL-induced OC formation, the appearance of OC-specific marker genes and bone-resorbing activity in vitro. Thonzonium bromide blocks the RANKL-induced activation of NF-κB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. Thonzonium bromide disrupts F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption. Thonzonium bromide exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis.
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In VitroThonzonium bromide inhibits RANKL-induced OC formation, the appearance of OC-specific marker genes and bone-resorbing activity in vitro. Thonzonium bromide blocks the RANKL-induced activation of NF-κB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. Thonzonium bromide disrupts F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption. Thonzonium bromide exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis.
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorDHPS
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number553-08-2
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Formula Weight591.71
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Molecular FormulaC32H55BrN4O
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Purity>98% (HPLC)
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SolubilityDMSO: > 10 mM
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SMILES[Br-].CCCCCCCCCCCCCCCC[N+](C)(C)CCN(CC1=CC=C(OC)C=C1)C1=NC=CC=N1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Lys05
Lys05 (Lys01 trihydrochloride, PS-1001)?is the water-soluble salt of Lys01, is a 10-fold more potent lysosomal autophagy inhibitor than hydroxychloroquine (HCQ); shows IC50 values of 3.6, 3.8, 6 and 7.9 uM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.
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SLLN-15
SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models.
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Neriifolin
Neriifolin (17β-Neriifolin), a cardiac glycoside extracted from the unripe fruit of Cerbera manghas, is a Na+K+-ATPase inhibitor with anticancer activity that inhibits cell proliferation by suppressing HOXA9-dependent gene expression and inducing apoptosis in the human acute myeloid cell line, THP-1.
