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Senicapoc

CAS No. 289656-45-7

Senicapoc( ICA-17043 )

Catalog No. M13889 CAS No. 289656-45-7

A potent, selective Gardos channel blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 37 In Stock
5MG 30 In Stock
10MG 49 In Stock
25MG 75 In Stock
50MG 99 In Stock
100MG 132 In Stock
200MG 197 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Senicapoc
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective Gardos channel blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM).
  • Description
    A potent, selective Gardos channel blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM); shows greater potency and selectivity than Clotrimazole; increases RBC K(+) content and hematocrit (Hct), decreases corpuscular hemoglobin concentration (MCHC) in a transgenic mouse model of sickle cell disease (SAD); orally active.Other Indication Phase 3 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ICA-17043
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Gardoschannel
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    289656-45-7
  • Formula Weight
    323.336
  • Molecular Formula
    C20H15F2NO
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
  • Chemical Name
    Benzeneacetamide, 4-fluoro-.alpha.-(4-fluorophenyl)-.alpha.-phenyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stocker JW, et al. Blood. 2003 Mar 15;101(6):2412-8. 2. Ataga KI, et al. Blood. 2008 Apr 15;111(8):3991-7. 3. Minniti CP, et al. Br J Haematol. 2011 Dec;155(5):634-6.
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