Tolbutamide( D 860 | NSC 23813 | NSC 87833 | U-2043 )

Catalog No. M15457 CAS No. 64-77-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Tolbutamide
Note

Research use only, not for human use.
Brief Description

Tolbutamide is an inhibitor of potassium channel, used for type II diabetes.
Description

Tolbutamide is an inhibitor of potassium channel, used for type II diabetes.
In Vitro

Western Blot Analysis Cell Line:Glioma cell Concentration:400 μM Incubation Time:24h Result:Increasing the level of Cx43.
In Vivo

Animal Model:Non-obese-diabetic mouse Dosage:125 mg/kg Administration:Supplemented in daily diet for 27 weeks Result:Showed 10 of 23 animals developed diabetes compared with 18 of 24 in the control groups.Animal Model:Pregnant mice Dosage:100 mg/kg, 400 mg/kg Administration:Intraperitoneal injection (i.p.) Result:Showed a significant reduction (50 %) in the frequency of living fetuses for the group of 400 mg/kg on day 13.
Synonyms

D 860 | NSC 23813 | NSC 87833 | U-2043
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

Potassium Channel
Research Area

Metabolic Disease
Indication

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1.Wray HL, et al, Biochem Biophys Res Commun. 1973, 53(1), 291-294.

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