Cart
sales@molnova.com
Doramapimod
CAS No. 285983-48-4
Doramapimod( BIRB 796 | BIRB-796 | BIRB796 )
Catalog No. M13869 CAS No. 285983-48-4
A highly potent p38 MAPK inhibitor with Kd of 0.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 28 | In Stock |
|
| 10MG | 45 | In Stock |
|
| 25MG | 65 | In Stock |
|
| 50MG | 84 | In Stock |
|
| 100MG | 116 | In Stock |
|
| 200MG | 213 | In Stock |
|
| 500MG | 358 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDoramapimod
-
NoteResearch use only, not for human use.
-
Brief DescriptionA highly potent p38 MAPK inhibitor with Kd of 0.1 nM.
-
DescriptionA highly potent p38 MAPK inhibitor with Kd of 0.1 nM; displays no activity on ERK1, IKK2b, ZAP-70, EGFR, PKA, PKC, etc.; shows inhibition of TNFα inTHP.1 with IC50 of 18 nM; orally active.
-
In Vitro——
-
In Vivo——
-
SynonymsBIRB 796 | BIRB-796 | BIRB796
-
PathwayMAPK/ERK Signaling
-
Targetp38 MAPK
-
Recptorp38α
-
Research AreaInflammation/Immunology
-
Indication——
Chemical Information
-
CAS Number285983-48-4
-
Formula Weight527.6572
-
Molecular FormulaC31H37N5O3
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(NC1=C2C=CC=CC2=C(OCCN3CCOCC3)C=C1)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5
-
Chemical NameUrea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Pargellis C, et al. Nat Struct Biol. 2002 Apr;9(4):268-72.
2. Regan J, et al. J Med Chem. 2002 Jul 4;45(14):2994-3008.
3. Gruenbaum LM, et al. Biochem Pharmacol. 2009 Feb 1;77(3):422-32.
molnova catalog
related products
-
Gossypetin
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.
-
VX-745
A potent and selective p38α kinase inhibitor with IC50 of 9 nM; shows 20-fold selectivity for p38α over p38β (Ki=220 nM) and no significant inhibition for MAP kinases (with the exception of MKK6).
-
CMPD-1
A potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM.
