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Home - Products - MAPK/ERK Signaling - p38 MAPK - Doramapimod

Doramapimod

CAS No. 285983-48-4

Doramapimod( BIRB 796 | BIRB-796 | BIRB796 )

Catalog No. M13869 CAS No. 285983-48-4

A highly potent p38 MAPK inhibitor with Kd of 0.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 35 In Stock
5MG 29 In Stock
10MG 48 In Stock
25MG 68 In Stock
50MG 86 In Stock
100MG 120 In Stock
200MG 220 In Stock
500MG 370 In Stock
1G 551 In Stock
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Biological Information

  • Product Name
    Doramapimod
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent p38 MAPK inhibitor with Kd of 0.1 nM.
  • Description
    A highly potent p38 MAPK inhibitor with Kd of 0.1 nM; displays no activity on ERK1, IKK2b, ZAP-70, EGFR, PKA, PKC, etc.; shows inhibition of TNFα inTHP.1 with IC50 of 18 nM; orally active.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BIRB 796 | BIRB-796 | BIRB796
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    p38α
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    285983-48-4
  • Formula Weight
    527.6572
  • Molecular Formula
    C31H37N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC1=C2C=CC=CC2=C(OCCN3CCOCC3)C=C1)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5
  • Chemical Name
    Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pargellis C, et al. Nat Struct Biol. 2002 Apr;9(4):268-72. 2. Regan J, et al. J Med Chem. 2002 Jul 4;45(14):2994-3008. 3. Gruenbaum LM, et al. Biochem Pharmacol. 2009 Feb 1;77(3):422-32.
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