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MW181 dihydrochloride
CAS No. 1628503-08-1
MW181 dihydrochloride( MW01-10-181SRM )
Catalog No. M12431 CAS No. 1628503-08-1
MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameMW181 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionMW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM.
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DescriptionMW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ; suppresses p38α MAPK activation, reduces tau phosphorylation, and decreases proinflammatory cytokine production, suppresses LPS-induced increases in mouse brain IL-1β, TNFα, IL-6, IL-10, and CXCL1 in mice, significantly increases synaptophysin protein expression and prevents cognitive impairment in the aged hTau mice.
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In Vitro——
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In Vivo——
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SynonymsMW01-10-181SRM
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38 MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number1628503-08-1
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Formula Weight——
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN,N-dimethyl-6-(naphthalen-1-yl)-5-(pyridin-4-yl)pyridazin-3-amine dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Maphis N, et al. Alzheimers Res Ther. 2016 Dec 15;8(1):54.
2. Bachstetter AD, et al. J Neuroimmune Pharmacol. 2014 Sep;9(4):454-60.
3. Watterson DM, et al. PLoS One. 2013 Jun 26;8(6):e66226.
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