Homoharringtonine

Research use only, not for human use.

Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies.

Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myelodysplastic syndrome . Homoharringtonine enhances the paracellular permeability of Caco-2 cell monolayers by modulating the protein expression and localization of claudin isoforms. Homoharringtonine has anti-Y and antileukemic activities, may have the potential ability to treat acute, chronic myeloid leukaemia and Gefitinib-resistant NSCLC.

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NSC 141633 | Omacetaxine Mepesuccinate

JAK/STAT Signaling

STAT

STAT3

Cancer

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26833-87-4

545.61

C29H39NO9

>98% (HPLC)

Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.

COC1=C[C@@]23[C@H](c4cc(OCO5)c5cc4CCN2CCC3)[C@@H]1OC([C@](O)(CCCC(C)(C)O)CC(OC)=O)=O

(S)-1-((11bS,12S,14aR)-13-methoxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)succinate

(-20℃)

With Ice Pack

≥ 2 years