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MNK8?

CAS No. 2055078-49-2

MNK8?( 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione )

Catalog No. M28976 CAS No. 2055078-49-2

3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MNK8?
  • Note
    Research use only, not for human use.
  • Brief Description
    3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .
  • Description
    3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .(In Vitro):MNK8 (50 μM, 0-48 h) increased Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1 .
  • In Vitro
    MNK8 (50 μM, 0-48 h) increases Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1.
  • In Vivo
    ——
  • Synonyms
    3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    Antifungal
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2055078-49-2
  • Formula Weight
    252.27
  • Molecular Formula
    C15H12N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 41.67 mg/mL (165.18 mM)
  • SMILES
    CN(C(C=C(c1cccc2ccccc12)N1)=O)C1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Estévez-Lao TY, Hillyer JF. Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses. Insect Biochem Mol Biol. 2014 Jan;44:12-22.
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