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MNK8?
CAS No. 2055078-49-2
MNK8?( 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione )
Catalog No. M28976 CAS No. 2055078-49-2
3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 32 | In Stock |
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| 5MG | 33 | In Stock |
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| 10MG | 53 | In Stock |
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| 25MG | 98 | In Stock |
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| 50MG | 132 | In Stock |
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| 100MG | 198 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMNK8?
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NoteResearch use only, not for human use.
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Brief Description3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .
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Description3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .(In Vitro):MNK8 (50 μM, 0-48 h) increased Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1 .
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In VitroMNK8 (50 μM, 0-48 h) increases Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1.
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In Vivo——
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Synonyms3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorAntifungal
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Research Area——
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Indication——
Chemical Information
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CAS Number2055078-49-2
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Formula Weight252.27
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Molecular FormulaC15H12N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 41.67 mg/mL (165.18 mM)
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SMILESCN(C(C=C(c1cccc2ccccc12)N1)=O)C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Estévez-Lao TY, Hillyer JF. Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses. Insect Biochem Mol Biol. 2014 Jan;44:12-22.
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