Cart
sales@molnova.com
MNK8?
CAS No. 2055078-49-2
MNK8?( 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione )
Catalog No. M28976 CAS No. 2055078-49-2
3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 32 | In Stock |
|
| 5MG | 33 | In Stock |
|
| 10MG | 53 | In Stock |
|
| 25MG | 98 | In Stock |
|
| 50MG | 132 | In Stock |
|
| 100MG | 198 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMNK8?
-
NoteResearch use only, not for human use.
-
Brief Description3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .
-
Description3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .(In Vitro):MNK8 (50 μM, 0-48 h) increased Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1 .
-
In VitroMNK8 (50 μM, 0-48 h) increases Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1.
-
In Vivo——
-
Synonyms3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione
-
PathwayJAK/STAT Signaling
-
TargetSTAT
-
RecptorAntifungal
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2055078-49-2
-
Formula Weight252.27
-
Molecular FormulaC15H12N2O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 41.67 mg/mL (165.18 mM)
-
SMILESCN(C(C=C(c1cccc2ccccc12)N1)=O)C1=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Estévez-Lao TY, Hillyer JF. Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses. Insect Biochem Mol Biol. 2014 Jan;44:12-22.
molnova catalog
related products
-
Hispidol
Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.
-
Nirsevimab
Nirsevimab (MEDI8897) is a recombinant human respiratory syncytial virus (RSV) monoclonal antibody with a modified Fc region, efficiently targeting RSV-B with a Kd value of 1.5 nM, and can be used to prevent RSV infection.
-
AS2863619
AS2863619 is an orally active?inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively).
