Cart
sales@molnova.com
Pelitinib
CAS No. 257933-82-7
Pelitinib( EKB-569 | WAY-EKB 569 | EKB569 | EKB 569 )
Catalog No. M13779 CAS No. 257933-82-7
A potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
|
| 5MG | 41 | In Stock |
|
| 10MG | 58 | In Stock |
|
| 25MG | 102 | In Stock |
|
| 50MG | 124 | In Stock |
|
| 100MG | 184 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 456 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePelitinib
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM.
-
DescriptionA potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM; inhibits autophosphorylation of the cytoplasmic domain of HER-2 with IC50 of 1.23 uM; shows 1-3 orders of magnitude higher IC50 value for Src, Cdk4, c-Met, Raf, and MEK/ERK; inhibits proliferation in NHEK, A431, and MDA-468 cells (IC50= 61, 125, and 260 nM, respectively); potently inhibits the EGFR phosphorylation in A431 xenografts, suppresses tumorigenesis in APCMin/+ mice.Lung Cancer Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsEKB-569 | WAY-EKB 569 | EKB569 | EKB 569
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR|HER2/ErbB2|MEK|Raf|Src
-
Research AreaCancer
-
IndicationLung Cancer
Chemical Information
-
CAS Number257933-82-7
-
Formula Weight467.9231
-
Molecular FormulaC24H23ClFN5O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: 16 mg/mL
-
SMILESO=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(F)C(Cl)=C3)C2=C1)/C=C/CN(C)C
-
Chemical Name2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wissner A, et al. J Med Chem. 2003 Jan 2;46(1):49-63.
2. Nunes M, et al. Mol Cancer Ther. 2004 Jan;3(1):21-7.
3. Torrance CJ, et al. Nat Med. 2000 Sep;6(9):1024-8.
molnova catalog
related products
-
AG-1557 hydrochlorid...
AG-1557 is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).
-
DBPR112
DBPR112 is an orally active furanopyrimidine-based EGFR inhibitor with IC50s of 15 nM for EGFRWT and 48 nM for EGFRL858R/T790M, capable of occupying the ATP-binding site and demonstrating significant antitumor efficacy.
-
PD158780
PD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily: EGFR ErbB2 ErbB3 and ErbB4 (IC50s: 8μM 49 nM 52 nM and 52 nM in cell assay).
