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Iganidipine

CAS No. 119687-33-1

Iganidipine( —— )

Catalog No. M33383 CAS No. 119687-33-1

Iganidipine（NKY 722） is a new water-soluble Ca2+ antagonist with antihypertensive activity for research and neurological related diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Iganidipine
  • Note
    Research use only, not for human use.
  • Brief Description
    Iganidipine（NKY 722） is a new water-soluble Ca2+ antagonist with antihypertensive activity for research and neurological related diseases.
  • Description
    Iganidipine is a Ca2+ antagonist.
  • In Vitro
    ——
  • In Vivo
    Iganidipine (0.03% solution) significantly increases optic nerve head (ONH) tissue blood velocity (NBONH)by 8 to 10% in treated eyes after a single administration (p<0.05) or by 18 to 35% after 7-, 14-, or 21-day twicedaily administration in rabbits (p<0.05). In monkeys, 0.03% and 0.1% Iganidipine significantly increases NBONH in treated eyes by 20 and 41% after 7-day (p<0.05) twice-daily administration, respectively.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    119687-33-1
  • Formula Weight
    526.62
  • Molecular Formula
    C28H38N4O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=C(C)NC(C)=C(C1C2=CC([N+]([O-])=O)=CC=C2)C(OCC(C)(CN3CCN(CC3)CC=C)C)=O)OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ishii K, et al. Iganidipine, a new water-soluble Ca2+ antagonist: ocular and periocular penetration after instillation. Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1169-77.?
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