Methylprodnisolone Sodium Succinate( Methylprednisolone sodium succinate | U 9088 | U-9088 | U9088 )

Catalog No. M13687 CAS No. 2375-03-3

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HNMR

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Product Name

Methylprodnisolone Sodium Succinate
Note

Research use only, not for human use.
Brief Description

A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.
Description

A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.
In Vitro

——
In Vivo

Animal Model:Male C57/BL mouse (6-8 weeks old, 20-23 g) injected with collagenase Dosage:30 mg/kg Administration:ip; at 2, 24 and 48 h after ICH Result:Significantly reduced permeability of the BBB and brain oedema and upregulated expression of ZO-1 and Occludin.
Synonyms

Methylprednisolone sodium succinate | U 9088 | U-9088 | U9088
Pathway

GPCR/G Protein
Target

Glucagon Receptor
Recptor

Glucagon Receptor| Glucocorticoid Receptor
Research Area

Inflammation/Immunology
Indication

——

CAS Number

2375-03-3
Formula Weight

496.53
Molecular Formula

C26H33N3O6
Purity

>98% (HPLC)
Solubility

Soluble in DMSO
SMILES

O=C([O-])CCC(OCC([C@@](O)(CC1)[C@](C[C@H](O)[C@@H]2[C@@]3(C)C=C4)(C)[C@@H]1[C@@H]2C[C@H](C)C3=CC4=O)=O)=O.[Na+]
Chemical Name

Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-6-alpha-methyl-, 21- (hydrogen succinate), monosodium salt

1.Owen HC, et al. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70.

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