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GLP-1R modulator L7-028
CAS No. 2648317-95-5
GLP-1R modulator L7-028( —— )
Catalog No. M35193 CAS No. 2648317-95-5
GLP-1R modulator L7-028 is a variant that enhances affinity for GLP-1 and (cAMP) signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | In Stock |
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| 10MG | 188 | In Stock |
|
| 25MG | 322 | In Stock |
|
| 50MG | 460 | In Stock |
|
| 100MG | 684 | In Stock |
|
| 200MG | 918 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGLP-1R modulator L7-028
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NoteResearch use only, not for human use.
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Brief DescriptionGLP-1R modulator L7-028 is a variant that enhances affinity for GLP-1 and (cAMP) signaling.
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DescriptionGLP-1R modulator L7-028 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetGlucagon Receptor
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RecptorGlucagon Receptor | cAMP
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Research Area——
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Indication——
Chemical Information
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CAS Number2648317-95-5
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Formula Weight392.49
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Molecular FormulaC24H28N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (254.78 mM; Ultrasonic )
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SMILESO=C(Nc1cccc(c1)C(=O)N1CCCCC1)c1cccc(OC2CCCC2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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des-His1-[Glu9]-Gluc...
Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.
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PF-06882961
PF-06882961 is an orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist. PF-06882961 shows mild to moderate damage to the heart, moderate to severe effects on the thymus gland (which helps with managing infection), mild to moderate stomach ulcers at the highest dose level given in the rat.
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GLP-1R Antagonist 1
GLP-1R Antagonist 1 is an orally active, CNS penetrant and non-competitive glucagon-like peptide 1 receptor (GLP-1R) antagonist (IC50: 650 nM).
