BCX-4430

Research use only, not for human use.

A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator.

A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator; exhibits broad-spectrum antiviral activity against negative-sense RNA viruses representing the Filoviridae, Arenaviridae, Bunyaviridae,Orthomyxoviridae,Picornaviridae and Paramyxoviridae families, and positive-sense RNA viruses of the Flaviviridae and Coronaviridae families (EC50=5-60 uM).Ebola Virus Infection Phase 1 Clinical.

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Animal Model:Female Syrian golden hamsters (hamsters infected with YF virus)Dosage:4 mg/kg of body weight Administration:I.p.; twice daily for 7 days Result:Significantly improved the survival of hamsters infected with YFV.

BCX4430 | Galidesivir

Microbiology/Virology

Filovirus

Filovirus

Infection

Ebola Virus Infection

222631-44-9

301.7294

C11H16ClN5O3

>98% (HPLC)

H2O: ≥ 41 mg/mL

C1=C(C2=C(N1)C(=NC=N2)N)C3C(C(C(N3)CO)O)O.Cl

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, hydrochloride (1:1), (2S,3S,4R,5R)-

(-20℃)

With Ice Pack

≥ 2 years