ST-148( ST148 )

Catalog No. M14372 CAS No. 400863-77-6

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Product Name

ST-148
Note

Research use only, not for human use.
Brief Description

ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays.
Description

ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein; exhibits a broad range of potencies with EC50 of 0.512, 1.150, and 2.832 uM for DENV-3, -4, and -1, respectively; significantly reduced viremia and viral load in vital organs and tended to lower cytokine levels in the plasma in a nonlethal model of DENV infection in AG129 mice.
In Vitro

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In Vivo

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Synonyms

ST148
Pathway

Microbiology/Virology
Target

Filovirus
Recptor

Filovirus
Research Area

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Indication

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CAS Number

400863-77-6
Formula Weight

421.537
Molecular Formula

C21H19N5OS2
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(C1=C(N)C2=CC3=C(CCCCC3)N=C2S1)NC4=NN=C(C5=CC=CC=C5)S4
Chemical Name

3-Amino-6,7,8,9-tetrahydro-5H-1-thia-10-aza-cyclohepta[f]indene-2-carboxylic acid (5-phenyl-[1,3,4]thiadiazol-2-yl)-amide

1. Byrd CM, et al. Antimicrob Agents Chemother. 2013 Jan;57(1):15-25. 2. Scaturro P, et al. J Virol. 2014 Oct;88(19):11540-55.

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