JH-XI-10-02( —— )

Catalog No. M13523 CAS No. 2209085-22-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

JH-XI-10-02
Note

Research use only, not for human use.
Brief Description

JH-XI-10-02 is a CDK8 PROTAC based on the CDK8 inhibitor JH-VIII-49, induces partial degradation of CDK8 in Jurkat cells with IC50 of 159 nM.
Description

JH-XI-10-02 is a CDK8 PROTAC based on the CDK8 inhibitor JH-VIII-49, induces partial degradation of CDK8 in Jurkat cells with IC50 of 159 nM.
In Vitro

Western Blot Analysis Cell Line:Jurkat cells Concentration:1 μM Incubation Time:6 and 24 hours Result:Partial degradation of CDK8 upon treatment for 6 h at a concentration of 1 μM. Significant degradation of CDK8 after treatment for 24 h at a concentration of 1 μM.Western Blot Analysis Cell Line:WT Molt4 and CRBN null Molt4 cells Concentration:0.1, 0.5, 1, 2, 5 μM Incubation Time:24 hours Result:Degradation of CDK8 at 5 μM in WT Molt4 cells. There were no degradation in CRBN null Molt4 cells at any concentration.
In Vivo

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Synonyms

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Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

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CAS Number

2209085-22-1
Formula Weight

920.161
Molecular Formula

C53H69N5O9
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (108.68 mM)
SMILES

CC12CCC(CC1CCC3C2CCC4(C3CCC4C5=CC6=C(C=C5)C=CN=C6)C)N(C)C(=O)CCOCCOCCOCCOCCNC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O
Chemical Name

1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((3S,5S,8R,9S,10S,13S,14S,17S)-17-(isoquinolin-7-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-N-methyl-3,6,9,12-tetraoxapentadecan-15-amide

1. John M. Hatcher, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00011

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